BGX - Flexible Bayesian clustering and partition models for gene expression data
Funded by the BBSRC Exploiting Genomics initiative, from May 2002 to February 2007.
BIG - Bayesian Integrative Genomics
A collaborative programme started in 2008, coordinated by Prof Sylvia Richardson
Technical reports & submitted publications
- Blangiardo M., Richardson S. (2007) A Bayesian calibration model for combining different pre-processing methods in Affymetrix chips, submitted, PDF, supplementary material, WinBUGS code
- Bottolo L., Richardson S. (2007) Fully Bayesian variable selection using g-priors, submitted, PDF abstract
- Brown A., Richardson, S., Petretto, E., Whittaker J, (2008) A multivariate shrinkage approach to expression Quantitative Trait Loci mapping, submitted, PDF abstract
- Ambler, G. K. and Green P. J. (2007)
Bayesian two-way clustering with applications to gene expression microarray data,
Technical report, School of Mathematics, University of Bristol
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Green P. J. (2007)
The coloured Dirichlet process: a probability model for clustering heterogeneously, in preparation.
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Lau, J. W. and Green P. J. (2007),
Bayesian Model Based Clustering Procedures.
To appear in Journal of Computational and Graphical Statistics. Technical report (PDF).
- Lau, J. W. and Green P. J. (2007)
Bayesian clustering using a heterogeneous Dirichlet process,
with application to parametric gene expression profiles, in final preparation.
Refereed journal publications
2008
- Zucknick, Manuela; Richardson, Sylvia; and Stronach, Euan A. (2008) "Comparing the Characteristics of Gene Expression Profiles Derived by Univariate and Multivariate Classification Methods" Statistical Applications in Genetics and Molecular Biology: Vol. 7 : Iss. 1, Article 7. journal page
2007
- Blangiardo M., Richardson S. (2007) Statistical tools for synthesizing lists of differentially expressed features in related experiments Genome Biology, 8, R54 journal page , with BGcom R package
- Bochkina N., Richardson S. (2007) Tail
posterior probability for inference in pairwise and multiclass gene expression
data, Biometrics, journal page, with supplementary material
- Lewin, A., Bochkina, N. and Richardson, S (2007) Fully Bayesian mixture model for differential gene expression: simulations and model checks. Statistical Applications in Genetics and Molecular Biology Vol. 6 : Iss. 1, Article 36. journal page BGmix software
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Lewin, A., Richardson, S. (2007)
Bayesian methods for microarray data, to appear in the Handbook of Statistical Genetics, eds D. Balding, M. Bishop and C. Cannings, Wiley (draft PDF)
- Turro, E., Bochkina, N. Hein, A.-M.K., and Richardson, S. (2007)
BGX: a Bioconductor package for the Bayesian integrated analysis of
Affymetrix GeneChips, BMC Bioinformatics 2007, 8:439 (journal page).
2006
- Broët, P. and Richardson S. (2006), Detection of gene copy
number changes in CGH microarrays using a spatially correlated mixture model. Bioinformatics 2006 22(8):911-918; doi:10.1093/bioinformatics/btl035
journal page
supplementary
material
CGHmix WinBUGS code
- Hein, A.-M.K., Lewin, A. and Richardson, S. (2006)
Bayesian hierarchical models for inference in microarray data. In Do KA, Muller, P, and Vanucci M (eds).
Bayesian inference for gene expression and proteomics. Cambridge University Press. p. 53-70
- Hein A.-M. and Richardson S. (2006), A powerful method for detecting differentially expressed genes from GeneChip arrays that does not require replicates. BMC Bioinformatics 2006, 7:353 doi:10.1186/1471-2105-7-353
journal page
- Lewin, A. and Grieve, I. (2006), Grouping Gene Ontology terms to improve the assessment of gene set enrichment in microarray data. BMC Bioinformatics 2006 7:426 doi:10.1186/1471-2105-7-426
journal page
- Lewin, A., Richardson, S., Marshall, C., Glazier, A. and Aitman,
T. (2006), Bayesian Modelling of Differential Gene Expression.
Biometrics 2006 62: 10
doi:10.1111/j.1541-0420.2005.00394.x journal page supplementary
material, including WinBUGS code
2005
- Hein, A.-M.K., Richardson, S., Causton, H.C., Ambler, G.K., Green,
P.J. (2005), BGX: a fully Bayesian gene expression index for Affymetrix
GeneChip data. Biostatistics, 2005 6(3):349-373; doi:10.1093/biostatistics/kxi016. journal page
Software
2004
- Broët, P., Lewin, A., Richardson, S., Dalmasso, C. and Magdelenat,
H. (2004), A mixture model based strategy for selecting sets of genes in
multiclass response microarray experiments. Bioinformatics 2004
20(16):2562-2571; doi:10.1093/bioinformatics/bth285. journal
page journal
TOC software
2002
- Broët, P., Richardson, S. and Radvanyi, F. (2002), Bayesian
Hierarchical Model for Identifying Changes in Gene Expression from Microarray
Experiments Journal of Computational Biology 9, 671-683. journal
page