Alex Lewin

Some Recent Presentations

Statistical Testing of Gene Enrichment, and fuzzy decision rules

Talk given at the 25th Leeds Annual Statistical Research Workshop, Leeds July 2006.
ppt

This presentation includes work from both **Lewin and Grieve 2006, BMC Bioinformatics** and **Kulinskaya and Lewin (submitted)**.

- Grouping GO terms to improve gene enrichment testing
- Fuzzy decision rules for multiple testing with discrete data

Predictive Model Checks in Bayesian Models

Poster given at the Valencia / ISBA Eighth World Meeting on Bayesian Statistics, Benidorm, June 2006.
ppt

This presentation describes recent work with Sylvia Richardson.

- Predictive checks for a mixture prior
- Mixed predictive p-values

Bayesian Hierarchical Model for Differential Gene Expression

Lecture given at the INSERM Workshop "Biostatistical Modelling of Postgenomic Data for Biomedical Research", Toulon, October 2005.
ppt

This presentation describes the work in **Lewin et al. 2006, Biometrics**.

- Simultaneous modelling of array normalization and differential expression
- Exchangeable model for gene variances
- Predictive model checks
- Analysing Gene Ontology terms of differentially expressed genes

Bayesian Mixture Model for Differential Gene Expression

Talk given at the European Statistician's Meeting, Oslo, July 2005. ppt

This presentation describes some recent work with Natalia Bochkina and Sylvia Richardson (submitted).

- Bayesian mixture model for differential gene expression
- Mixture prior with a point mass for the null hypothesis

Semi-parametric Mixture Model for Gene Expression Profiles

Poster presented at 'Mathematical and Statistical Aspects of Molecular Biology XIV', Cambridge, March 2004 and 'Statistics in Functional Genomics' Workshop, Ascona July 2004. pptThis poster presents the work in

- Mixtures with variable number of components
- Semi-parametric model for alternative hypothesis
- Bayesian estimation of the False Discovery Rate

This seminar includes work from both

- Bayesian hierarchical model for differential expression
- Predictive model checks
- Semi-parametric mixture model
- Bayesian estimation of the False Discovery Rate

Multiple Testing:

Seminar given as part of the Statistical Advisory Service Seminar Series, Imperial College, March 2005. pdf

- Bonferroni correction
- False discovery rate / positive false discovery rate
- Controlling error rates, step-wise procedures
- Benjamini and Hochberg, Storey methods
- FDR in Bayesian framework

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